Friday, April 20, 2018

Dr. Duello Advancing Dental Education in Our Community


This was the subject of the Open House and mini CE course at our office this past Wednesday night. Dr. Duello continues to work hard to bring the best of the growing digital technologies to his practice and share the benefits of these technologies with the St. Louis dental community.

The X-Guide by X-Nav Technologies was the darling of the night.  This GPS guided surgery technology has made "perfect" implant placement a reality. X-Guide allows for the transfer of the 3D treatment plan direct to the patient's mouth for the surgical procedure utilizing GPS technology to precisely place dental implants. Basically, it creates a virtual surgical guide rather than a physical one, thus reducing the margin of error to .222microns.
Dr. Duello demonstrating X-Guide 
Dr. Duello in our teaching facility with a group local dentists

Dr. Duello continues to embrace the burgeoning growth of the digital world in dentistry because it ultimately allows the dental practitioner to give patients what they truly want: less time in the dental chair and a  very predictable outcome.

Friday, April 6, 2018

Periodontal Disease and Age-Related Macular Degeneration

Gum Disease May Cause Blindness

We've been reporting that periodontal disease is associated with many systemic inflammatory diseases, but now there is emerging evidence that a specific bacteria may contribute to age-related macular degeneration.

The anaerobic gram-negative bacteria Porphyromonas gingivalis (Pg) is the root of this evil. If you or a loved one have symptoms of gum disease then you need to act. Gum treatments are a relatively easy way to prevent devastating systemic diseases that can threaten your eyesight and even your life. Below is a synopsis of the new research into the age-related macular degenration that is associated with Pg.

Many clinical studies link Chronic Periodontitis (CP) to various systemic disorders and lately age-related macular degeneration (AMD), a leading cause of irreversible vision loss in elderly, is found to be associated with periodontal disease. The keystone oral-pathobiont and one of the major causative organism for CP, Porphyromonas gingivalis (Pg), has been identified with the ability to invade epithelial, fibroblasts and dendritic cells. "Our study was designed with an objective to interrogate the role of Pg and its fimbriae-mediated infection of human retinal-pigment epithelial cells and retro-orbitally injected mice retina, thus revealing possible molecular links between CP and AMD," said Hyun Hong (Predoctoral dental student, Summer Research Program, Dental College of Georgia) and Dr. Pachiappan Arjunan, the Principal Investigator, who directed this study (Assistant Professor, Department of Periodontics, Dental College of Georgia, Augusta University).
Human retinal-pigment epithelial cells were infected with Pg and its isogenic mutant strains and genes were analyzed by qPCR.
The results showed that human retinal-pigment epithelial cells take up Pg381 and that qPCR shows a significant increase in expression levels of genes, important in immunosuppression and angiogenesis/neo-vascularization markers compared with uninfected control.
Certain complement regulatory-related genes were upregulated, while others were downregulated. In a mouse model, AMD-related effects on mouse retinae were induced by Pg-injection compared to control group.
Dr. Arjunan states that, "This is the first study to demonstrate the link between oral pathobiont infection and AMD pathogenesis and that Pg can invade human retinal-pigment epithelial cells & elevate AMD-related genes which might be the target molecules for both diseases."
Further, successive ongoing studies in Dr. Arjunan's laboratory in collaboration with Dr. Christopher W Cutler (Professor and Chair, Department of Periodontics, Dental collage of Georgia, Augusta University), could distinguish specific causal role of Pg in AMD pathogenesis. The first part of this work will be published very soon, he added.
This work was funded by the Department of Periodontics, Dental College of Georgia, Augusta University and seeks additional funding support from National Institutes of Health (NIH) to accomplish the objective of this innovative study.
At the 47th Annual Meeting of the American Association for Dental Research (AADR), held in conjunction with the 42nd Annual Meeting of the Canadian Association for Dental Research (CADR), Hyun Hong, The Dental College of Georgia at Augusta University, presented a poster titled "Investigating the Enigmatic Link Between Periodontal Inflammation and Retinal Degeneration."
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